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However, as noted by Chen and colleagues 52 , this increase in FXR signaling could also be connected to depressive symptoms in FM

509 Clinical evidence indicates that the expression of ER stress-related proteins such as IRE1, PERK, and CHOP is reduced in SLE patients, while the levels of XBP1 and midbrain astrocyte-derived neurotrophic factor (MANF) are elevated, suggesting their potential role in disease development

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