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[9] High-dose niacin (used to treat cholesterol) lacks human safety data in pregnancy and could theoretically affect the fetus (for example, by causing hypotension or altering lipid metabolism)

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Finally, one very recent study in the USA has demonstrated that in some individuals with neurological symptoms, the presence in the blood of antibodies against this receptor may interfere with the proper uptake of B12 into the brain

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159 One major way it produces this effect is by sponging up destructive reactive nitrogen species, such as peroxynitrite