These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue
While individuals with mild vitamin B 12 deficiency may not experience symptoms, blood homocysteine and/or MMA may be elevated (18)
For extended storage, aliquot into sterile containers and freeze at -20C
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