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Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]

Consequently, glutamine metabolism has emerged as a pivotal regulator in maintaining immune cell homeostasis

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Antigen-presenting cells (APCs) may process and present altered proteins/peptides, generating novel epitopes and activating target B and T cells, leading to an autoimmune response against melanocytes (76)