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All three RAMPs can interact with CTR, and this gives rise to three discrete Amy receptor phenotypes, AMY 1 R, AMY 2 R and AMY 3 R, with RAMP1, RAMP2, and RAMP3, respectively 7,8

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However, in 2019, they only budgeted 15 million dollars towards ME/CFS research, whereas 111 million dollars and 94 million dollars was donated to MS and RA research, respectively (both of which already have drugs on the market)