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HGMSCs treated with AEDG peptide showed upregulation of all the studied markers: Nestin, GAP43, -tubulin III and Doublecortin (Figure 2)

4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2

First , it is the rate-limiting cofactor for collagen biosynthesis specifically for the hydroxylation of proline and lysine residues that allow the collagen triple helix to form correctly

Despite these advances, several critical challenges continue to impede the practical clinical translation of CQDs [103]