This pressure can result in lid tenderness and inflammation, gland shortening, atrophy and loss, recurrent eyelid infections (stye, hordeola, chalazia, cellulitis), and the classic symptoms of ocular irritation associated with dry eye, Meibomian gland dysfunction, blepharitis, and ocular rosacea
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while they act as secondary messengers in various key physiological phenomena, they also induce oxidative damages under several environmental stress conditions like salinity, drought, cold, heavy metals, UV irradiation etc., when the delicate balance between ROS production and elimination, necessary for normal cellular homeostasis, is disturbed