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This suggests that strengthening state tobacco control programs should further reduce smoking prevalence in all states, even in those with already low smoking prevalence such as California and Utah

We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

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Frustration with continued tobacco use: Several participants expressed frustration about filling prescriptions to treat tobacco-related diseases or for medications that could negatively interact with tobacco when they suspected that patients would continue to smoke

Manufacturers and importers will be required to place graphic and text health warnings on packaging and in tobacco advertising