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Once-daily dosing of this compound for 7 days in in vivo experiments, not only increased the activation of TrkB in the hippocampus and striatum, but also significantly improved the impairment in motor learning, following traumatic brain injury

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From these values, it is clear that the ascorbate monoanion AscH can react with the tocopherol radical (-Toc-O ) to regenerate vitamin E (-Toc-OH) (Poprac et al

The rostral two burr holes were placed just basal from the posterior interocular line, the basal two burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes