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Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation
Might be used as a starting point for new approaches in cancer drug discovery
FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42
The protocol is simple and rapid with a high yield
Trametinib Pack Size:5 mg Disrupts peptide transfer on ribosomesTrametinib (GSK1120212; JTP 74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis.
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