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AGEs may cause vascular dysfunction by making cross-bonds between extracellular matrix proteins (elastin and collagen), which leads to blood vessel stiffness, heart fibrosis, and diastolic dysfunction 12

FASEB J (2014) 28:41629.10.1096/fj.13-229591 87 NovakNAllamJP

Cycling protocols Users typically cycle peptides (e.g., eight to 12 weeks) to avoid desensitization and minimize potential side effects, though optimal protocols are not firmly established in long-term clinical trials

Avian pathogenic Escherichia coli alters complement gene expression in chicken erythrocytes