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ClinicalTrials.gov A Study of Retatrutide (LY3437943) Once Weekly in Adults With Obesity and Knee Osteoarthritis (TRIUMPH-4)

15 Similarly, increased generation of NAD + via the KP in resting, aged or immune-challenged macrophages restores OXPHOS and homeostatic immune responses, whereas inhibition of de novo NAD + synthesis induces an increased inflammation-associated TCA-cycle metabolite succinate and elevated mitochondria-generated ROS, resulting in rising innate immune dysfunction in aging and age-associated diseases

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The evidence of new bone formation covered a smaller area of the bone marrow, at the expense of the formation of cortical bone in the treated animals compared to the cortex in the control animals

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