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"We need to first ensure, before heat-not-burn reaches the market, that consumers are aware we don't have all the facts on heat-not-burn products, and then we should begin filling in those knowledge gaps," Caputi said

Smoking cessation therapies such as Bupropion and nicotine replacement have been used successfully, although the exact risks are still unknown

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While emphasizing that e-cigarettes are not harmless for nonsmokers, the FDA and NIH recognize they could be a form of harm reduction and have called for more clinical trials into the safety and effectiveness of e-cigarettes as an aid in smoking cessation