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(JPAD) Unregulated clinics may use non-pharmaceutical powders, poor compounding techniques, or non-sterile equipment raising the risk of endotoxin contamination, infection and severe immune reactions

Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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10.1016/j.ijantimicag.2007.06.011 102