Srinivasan, V
Intravenous administration bypasses the digestive tract, where oral glutathione largely breaks down, so the full dose reaches the blood
However, limited ionic interaction was observed as follows: Arg152 with Ferrostatin
To date, 14 studies have investigated GSH, GSSG, GSH/GSSG and/or tGSH levels in the plasma of healthy adults (Andriollo-Sanchez et al., 2005, Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Kretzschmar et al., 1991, Maciejczyk et al., 2019, Michelet et al., 1995, Nuttall et al., 1998, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), with the majority using HPLC (N = 10, 71%) (Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Michelet et al., 1995, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), and the remaining using colorimetry (N = 2, 14%) (Kretzschmar et al., 1991, Maciejczyk et al., 2019), enzyme-rate essay (Nuttall et al., 1998) (N = 1, 7%), and spectrophotometry (N = 1, 7%) (Andriollo-Sanchez et al., 2005) (Table 3)
Since oxidation participates as an essential messenger of cellular signaling pathways, treatment of oxidative stress needs to consider maintaining that physiologic threshold (230, 231)
