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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.von Bartheld C.S., Bahney J., Herculano-Houzel S

S., Moura, D

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In addition, in a subgroup of women with normal baseline homocysteine levels who received the supplement, AMH levels increased, suggesting improved ovarian function