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If nausea persists beyond 3-4 weeks on a stable dose, consider reducing to the previous dose level and attempting re-escalation more gradually after 4-6 weeks

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doi: 10.1159/000374065 236 Elliot MurphyRBanerjeeA

A mass spectrometry-based proteomic approach for identification of serine/threonine -phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate