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Treatment duration is limited to two years, both because of regulatory guidelines related to an osteosarcoma signal in rat studies (which has not been observed in humans, and the original black box warning has been removed) and because efficacy tends to plateau

107(6):771781 Endocrine and metabolic roles of insulin-like growth factor signaling in experimental models Sjgren K, Jansson JO, Isaksson OG, Ohlsson C., Minerva Endocrinologica , 2002

Resulting concentration: 25 mg/mL

2017 Dec 28

Food and Drug Administration) FDA also flags thymosin beta-4 fragment with lack of human exposure data and insufficient safety information