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Originally identified in a screen for compounds selectively lethal to RAS-mutant cancer cells, RSL3 triggers ferroptotic cell death by inactivating GPX4, leading to the accumulation of toxic amounts of reactive oxygen species (ROS) and subsequent oxidative membrane damage [1]

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To complicate matters further, the gene for cystathionine -synthase is also on chromosome 21 (21q22.3)

However, whether the universality of this criterion is limited by ethnicity, region and gender remains to be further studied

Be aware of these potential reactions and consult your healthcare provider if you experience any unusual symptoms